Potential research projectsI have several projects that would be suitable for Honours, Masters or PhD students. These are just some examples, and there are lots of projects available. If you are interested in studying any of these (or if you have your own idea for a project), please get in touch with me.
Aquatic ecosystems and fishingMulti-species communities are often described by food webs, which focus on species as the key variable determining what an individual eats. But in marine ecosystems, fish can grow by several orders of magnitude during their lives, and their diet changes as they do so. This means that body size can be more important than species identity in describing predator-prey interactions. Size-specturm models focus on body size as a key variable and keep track of how biomass flows from prey to predator through mortality and growth. In reality, size and species are both important factors and need to be considered together. This project will use size-based models to investigate the dynamics of multi-species communities. These models will also be used to investigate different fishing strategies with the twin goals of maximising yield while minimising ecosystem impact.
Collective cell behaviourCollective cell behaviour is the driving force behind many physiological processes, including embryonic development, tissue repair and tumour growth. Experiments on collective cell behaviour typically collect data at the level of the population rather than the individual cell. We’d like to be able to translate data from observing populations of cells into knowledge about how individual cells work and how they interact with their neighbours. This project will approach this problem using approximate Bayesian computation (ABC). At its simplest, this involves sampling model parameters from a prior distribution and simulating cell behaviour. If the model output is “close” to the experimental data, the parameter values are accepted as part of the posterior distribution, otherwise they are rejected. This will be used to estimate quantities such as cell proliferation and movement rates and the strength of interactions with neighbouring cells.
This project will require some experience of a computer programming language, e.g. Matlab and an interest in working with biological data. Prior knowledge of Bayesian statistics is NOT required.