Electro-permeabilization of a prolate spheroidal model of biological cells
David J.N. Wall, Andrew T. Shanks and Patrick Bodger
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Abstract
The extent of mathematical analysis for electro-permeabilization of biological cells has thus far been constrained to spherical models. In this paper, the spherical model is extended to a prolate spheroidal balloon model, which is considered more representative of many real cells under actual field conditions.
It is shown that the size dependence of the dielectric voltage breakdown for the spheroidal cells can be eliminated. This also reduces the dependence of the breakdown on the eccentricity of the spheroidal cells over a range of shapes. It is shown that dielectric breakdown of needle shaped cells will occur at higher applied fields than spherical ones.
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